Ribosomal Mutations and Resistance: We identified specific mutations in the uL4 and uL22 ribosomal proteins that confer resistance to macrolides The paradox of macrolide resistance in Pseudomonas aeruginosa 1 uL4 and uL22 protein mutations in clinical strains of Pseudomonas aeruginosa. a) Localization and structure of the ribosomal uL4 protein in P. aeruginosa
We demonstrate that macrolides are, instead, effective antibiotics against P. aeruginosa airway infections in an Air-Liquid Interface (ALI) infection model Macrolide resistance through uL4 and uL22. 4 ribosomal mutations in Pseudomonas aeruginosa. 5. 6. 7. 8. Lise Goltermann1, Pablo Laborda1, Oihane Macrolide resistance through uL4 and uL22 ribosomal mutations in
Macrolide therapy in Pseudomonas aeruginosa infections causes Pseudomonas aeruginosa: persistence beyond antibiotic resistance
uL4 and uL22 protein mutations in clinical strains of Pseudomonas aeruginosa. a) Localization and structure of the ribosomal uL4 protein in P. New preprint out! Our latest work challenges the conventional belief that #Pseudomonas aeruginosa is intrinsically resistant to #Macrolides 19. Goltermann, L. Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa. Nat. Commun. 2024; 15:8906.
We found no other studies published addressing the emergence of macrolide resistance through uL4 or uL22 mutations in P. aeruginosa. Added uL4 and uL22 ribosomal proteins [ Macrolide therapy in Pseudomonas aeruginosa infections causes uL4 ribosomal protein mutations leading to high-level aeruginosa airway infections. Additionally, we analyzed the impact of macrolide treatment on the accumulation of uL4 and uL22 ribosomal protein mutations in P.
EPS8.04Macrolide resistance through uL4 and uL22 ribosomal